Publications
Axelsson E, Sandmann T, Horn T, Boutros M, Huber W, Fischer B. (2011). Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi. BMC Bioinformatics. 12(1):342.
Horn T, Sandmann T, Fischer B, Axelsson E, Huber W, Boutros M. (2011). Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Nat Methods. 8(4):341-6.
Schnorrer F, Schönbauer C, Langer CC, Dietzl G, Novatchkova M, Schernhuber K, Fellner M, Azaryan A, Radolf M, Stark A, Keleman K, Dickson BJ. (2011). Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Nature.464(7286):287-91.
Gontijo AM, Miguela V, Whiting MF, Woodruff RC, Dominguez M. (2011). Intron retention in the Drosophila melanogaster Rieske Iron Sulphur Protein gene generated a new protein. Nat Commun. 2:323.
Ragab A, Buechling T, Gesellchen V, Spirohn K, Boettcher AL, Boutros M. (2011). Drosophila Ras/MAPK signalling regulates innate immune responses in immune and intestinal stem cells. EMBO J. 30(6):1123-36.
Vallejo DM, Caparros E, Dominguez M. (2011). Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. EMBO J. 30(4):756-69.
Horn T, Sandmann T, Boutros M. (2010). Design and evaluation of genome-wide libraries for RNA interference screens. Genome Biol. 11(6):R61.
Bina S, Wright VM, Fisher KH, Milo M, Zeidler MP. (2010). Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation. EMBO Rep. 11(3):201-7.
Pau G, Fuchs F, Sklyar O, Boutros M, Huber W. (2010). EBImage - an R package for image processing with applications to cellular phenotypes. Bioinformatics. 26(7):979-81.
Bourgon R, Gentleman R, Huber W. (2010). Independent filtering increases detection power for high-throughput experiments. Proc Natl Acad Sci USA. 107(21):9546-51.
Gutierrez-Aviño FJ, Ferres-Marco D, Dominguez M. (2009). The position and function of the Notch-mediated eye growth organizer: the roles of JAK/STAT and four-jointed. EMBO Rep. 10(9):1051-8.
Grusche FA, Hidalgo C, Fletcher G, Sung HH, Sahai E, Thompson BJ. (2009). Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]. BMC Dev Biol. 9:14.
Liu T, Sims D, Baum B. (2009). Parallel RNAi screens across different cell lines identify generic and cell-type specific regulators of actin organisation and cell morphology. Genome Biol.;10(3):R26.
Sims D, Duchek P, Baum B. (2009). PDGF/VEGF signaling controls cell size in Drosophila. Genome Biol. 12;10(2):R20.
Xu Z., Wei W., Gagneur J., Perocchi F., Clauder-Münster S., Camblong J., Guffanti E., Stutz F., Huber W., Steinmetz L.M. (2009). Bidirectional promoters generate pervasive transcription in yeast. Nature 457(7232): 1033-1037.
Basanta D, Miodownik M, Baum B. (2008). The evolution of robust development and homeostasis in artificial organisms. PLoS Computational Biology 4(3), e1000030.
Boutros M. and Ahringer, J. (2008). The art and design of genetic screens: RNA interference. Nature Rev. Genet., 9:554-566.
Dominguez M. and F. Berger (2008). Chromatin and Cell Cycle Meeting in Madrid. Development. Nov;135(21):3475-80. MEETING REPORT
Georgiou M., Marinari E., Burden J., Baum B. (2008). Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability. Curr Biol.18(21):1631-8.
Mancera E., Bourgon R., Brozzi A., Huber W., Steinmetz L.M. (2008). High-resolution mapping of meiotic crossovers and non-crossovers in yeast. Nature 454(7203): 479-485.
Weber U., Pataki C., Mihaly J. and Mlodzik M. (2008). Combinatorial signaling by the Frizzled/PCP and Egfr pathways during planar cell polarity establishment in the Drosophila eye. Dev. Biol. 316:(1) 110-123.
Dietzl G, Chen D, Schnorrer F, Su KC, Barinova Y, Fellner M, Gasser B, Kinsey K, Oppel S, Scheiblauer S, Couto A, Marra V, Keleman K, Dickson BJ (2007). A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 448(7150):151-6.
Palomero T., Sulis M. L., Cortina M., Real P. J., Barnes K., Ciofani M., Caparros E., Buteau J., Brown K., Perkins S. L., Bhagat G., Mishra A., Basso G., Parsons R., Zúñiga-Pflücker J. C., Dominguez M., and Adolfo A. Ferrando (2007). Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nature Medicine 13(10):1203-10.
Bartscherer, K., N. Pelte, D. Ingelfinger, and M. Boutros. (2006). Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell, 125:523-33.
Boutros M., Bras L., Huber W. (2006). Analysis of cell-based RNAi screens. Genome Biology 25;7(7): R66.
Dominguez, M. (2006). Interplay between Notch and epigenetic silencers in cancer. Cancer Res. 66(18):8931-4.
Ferres-Marco D. , Gutierrez-Garcia I., Vallejo DM., Bolivar J., Gutierrez-Avino FJ., Dominguez M. (2006). Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. Nature 439:430-436.
Sims, D., Bursteinas, B., Gao, Q., Zvelebil, M., Baum, B. (2006). FLIGHT: database and tools for the integration and cross-correlation of large-scale RNAi phenotypic datasets. Nucleic Acids Research, Database issue 34: D479-83.
Thompson BJ, Cohen SM. (2006). The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. Cell. 126(4):767-74.
Gesellchen, V., D. Kuttenkeuler, M. Steckel, N. Pelte, and M. Boutros. (2005). An RNAi screen identified a Role for IAP2 in Innate Immune Response in Drosophila. EMBO reports, 6:979-84.
Muller, P., D. Kuttenkeuler, V. Gesellchen, M. Zeidler, and M. Boutros. (2005). Identification of JAK/STAT signaling components by genome-wide RNAi. Nature, 436:871-5.
Thompson BJ, Mathieu J, Sung HH, Loeser E, Rørth P, Cohen SM (2005). Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev Cell. 9(5):711-20.